Mediterranean spotted fever and its complications in Mostaganem, Algeria‎

  • Authors

    • Bestaoui S. Faculty
    • Amar NH Department of Infectious Diseases , University of Medicine Mostaganem, Algeria
    • Fellah M Department of Infectious Diseases , University of Medicine Mostaganem, Algeria
    • Bouhalloufa HF Department of Medicine, University of Medicine Mostaganem, Algeria
    • Salam F anguage Laboratory , University of Medicine Mostaganem, Algeria

    Received date: February 3, 2025

    Accepted date: February 25, 2025

    Published date: February 25, 2025

    https://doi.org/10.14419/xhk8y502
  • Mediterranean Spotted Fever; Rickettsia Conorii; Rickettsiosis; Brown Dog Tick; Intracellular ‎Bacteria
  • Abstract

    Mediterranean Spotted Fever (MSF) is an ancient anthropozoonosis of bacterial origin, in which ‎the cause is Rickettsia conorii in which the vector of transmission to humans is the brown dog ‎tick by bite. It is a seasonal disease raging in an endemic state in the Mediterranean region, ‎including our region of Mostaganem (Western Algeria). It was a retrospective study based on ‎the records of hospitalized patients at the infectious diseases department in Mostaganem, ‎recording 36 cases of MSF, from 2023 to 2024. The majority of patients were male and had ‎been in contact with dogs, both domestic and wild. In addition, the majority had a history of ‎diabetes or hypertension and had taken antibiotics before hospitalization. Complications were, ‎therefore, described in 12 of the 36 patients and were mainly nephrological, articular, cardiac, ‎etc. The Direct Current (DC) of our patients was based on Raoult’s diagnostic criteria given the ‎endemic zone, because of the non-availability of serology, or the polymerase chain reaction ‎‎(PCR) test. Although It remains a benign disease, it can be responsible for serious ‎complications, whether reversible or not. It must be systematically evoked in the face of febrile ‎eruptions during hot seasons in countries around the Mediterranean, including ours‎.

  • References

    1. Psaroulaki A ∙ Germanakis A ∙ Gikas A . Premier isolement et identification génotypique deRickettsia conorii Malish 7 chez un patient en Grèce. Eur J Clin Microbiol Infect Dis. 2005; 24:297-298 https://doi.org/10.1007/s10096-005-1304-z.
    2. De Sousa R., Nobrega S. D., Bacellar F., and Torgal J. Mediterranean spotted fever in Portugal: risk factors for fatal outcome in 105 hospitalized patients, Annals of the New York Academy of Sciences. (2003) 990, 285–294, 2-s2.0-0038390985. https://doi.org/10.1111/j.1749-6632.2003.tb07378.x.
    3. Bouchaib H. et al. Tick-and flea-borne rickettsioses in Tizi-Ouzou, Algeria: Implications for travel medicine, Travel Med Infect Dis (2018)][ Mouffok N. et al. Mediterranean spotted fever in Algeria--new trends. Int J Infect Dis (2009) https://doi.org/10.1016/j.tmaid.2018.11.005.
    4. Socolovschi C. et al.Influence of temperature on the attachment of Rhipicephalus sanguineus ticks on rabbits. Clin Microbiol Infect (2009) https://doi.org/10.1111/j.1469-0691.2008.02260.x.
    5. La Scola B, RaouLt D - Laboratorydiagnosis of rickettsioses: current approaches to diagnosis of old and new rickettsial diseases. J Clin Microbiol 1997 ; 35 : 2715-2227. https://doi.org/10.1128/jcm.35.11.2715-2727.1997.
    6. Vitaliti G, Falsaperla R, Lubrano R, Rapisarda V, Cocuzza S, Nunnari G, Pavone P. Incidence de la fièvre pourprée méditerranéenne chez les enfants siciliens : une étude rétrospective observationnelle clinico-épidémiologique de 1987 à 2010. Revue internationale des maladies infectieuses. Volume 31, février 2015, pages 35-40. https://doi.org/10.1016/j.ijid.2014.11.001.
    7. Anton E, Font B, Munoz T, Clinical and laboratory characteristics of l44 patients with Mediterranean spotted fever. Eur J Clin Micro-biol Infect Dis2003;22:126–8. https://doi.org/10.1007/s10096-002-0879-x.
    8. Caisso C. et al. A case of uveitis due to Rickettsia conorii infection in Southeastern France Ticks Tick Borne Dis. (2016)][Parola P, El-din C. La fièvre boutonneuse méditerranéenne : actualités The Mediterranean. Spotted fever: actuality. Revue Francophone des Labora-toires. Volume 2019, Issue 513, June 2019, Pages 55-60. https://doi.org/10.1016/S1773-035X(19)30289-8.
    9. Bousser M G, Mas JL. Accidents vasculaires cérébraux. Lancet Neurol. 2009; 8:643-653.
    10. Eldin C. et al. Limitations of diagnostic tests for bacterial infections. Med Mal Infect (2019). https://doi.org/10.1016/j.medmal.2018.12.004.
    11. Parola P, Eldin C. La fièvre boutonneuse méditerranéenne : actualités The Mediterranean. Spotted fever: actuality. Revue Francophone des Laboratoires. Volume 2019, Issue 513, June 2019, Pages 55-60. https://doi.org/10.1016/S1773-035X(19)30289-8.
    12. Papaa A, Dallab V, Petalac A, Maltezoud H.C, Maltezos E. Fatal Mediterranean spotted fever in Greece. BacteriologyVolume 16, Issue 6p589-592June 2010. https://doi.org/10.1111/j.1469-0691.2009.02910.x.
    13. Kleine-Tebbe J, Heinatz A, Gräser I, Dautel H, Hansen GN, Kespohl S, Rihs HP, Raulf-Heimsoth M, Vater G, Rytter M, Haustein UF. Bites of the European pigeon tick (Argas reflexus): Risk of IgE-mediated sensitizations and anaphylactic reactions. J Allergy Clin Im-munol. 2006 Jan;117(1):190-5. https://doi.org/10.1016/j.jaci.2005.08.056.
    14. Boulanger N, Lipsker D. Protection contre les piqûres de tiquesProtection against tick bites. Volume 142, Issue 4, April 2015, Pages 245-251. Annales de Dermatologie et de Vénéréologie. https://doi.org/10.1016/j.annder.2014.11.018.
    15. Ibrahim Montasser D, Zajjari Y, Alayoud A, Bahadi A, Aatif A, Hassani K, Hamzi A, Allam M. Acute renal failure as a complication of Mediterranean spotted fever. Néphrologie and Thérapeutique. Volume 7, Issue 4, July 2011, Pages 245-247. https://doi.org/10.1016/j.nephro.2011.02.002.
    16. Raoult D et al. Rickettsioses as paradigms of new or emerging infectious diseases. Clin Microbiol Rev 1997. https://doi.org/10.1128/CMR.10.4.694.
    17. Skhiri H, Zellama D, Aloui S, Bouraoui S, Frih MA, Achour A, Ben Dhia N, ElMay M. Insuffisance rénale aiguë au cours de la fièvre boutonneuse méditerranéenne : description de trois observations. Med Tropicale, 2004, Vol 64, Num 1, pp 58-60.
    18. Thèse : “La fièvre boutonneuse méditerranéenne à Tlemcen”. Université de Tlemcen, 2021 : https://dspace.univ-tlemcen.dz/bitstream/112/9423/1/Fievre-Boutonneuse-Mediterraneenne-a-Tlemcen.
    19. Hammami F, Koubaa M, Chakroun A, Smaoui F, Marrakchi C, Rekik K, Ben Jemaa M. Forme neurologique de la fièvre boutonneuse méditerranéenne. Rev Neurol (Paris). 2021;177(5):472-478. Revue Neurologique 2021. https://doi.org/10.1016/j.neurol.2021.02.235.
    20. Boulahri T, Taous A, Aït Berri M, Traibi I, Elbenaye J, Rouimi A. Infarctus cérébral révélant une fièvre boutonneuse méditerranéenne. Pan Afr Med J. 2017;26:80. https://doi.org/10.11604/pamj.2017.26.80.11434.
    21. Hsaini Y, MounachJ , Zerhouni H, Satté A, Mosseddaq R. Complications neurologiques de la fièvre boutonneuse méditerranéenne : à propos de cas. Rev Neurol (Paris). 2017;173(Suppl 1):A12.
    22. Berriche A, Ammari L, Abdelmalek R, Kanoun F, Ghoubontini A, Kilani B, Tiouiri Benaissa H. Complications neurologiques au cours de la fièvre boutonneuse méditerranéenne. Rev Neurol (Paris). 2014;170(Suppl 1):A30. https://doi.org/10.1016/S0399-077X(14)70186-6.
    23. Sargsyan A, "Essential Notes on Pathophysiology for Advanced Practice Nurses", Digital Commons @ East Tennessee State Universi-ty, 2020.
    24. Gospodinova M, Nenova M, "Mediterranean Spotted Fever in Adults Aged Over 60 Years", 'Medical University Prof. Dr. Paraskev Stoyanov - Varna', 2003.
    25. "Skills in Rheumatology", 'Springer Science and Business Media LLC', 2021.
    26. Nilsson K, Lindquist O,Pahlson. Association of Rickettsia helvetica with chronic perimyocarditis in sudden cardiac death. Lan-cet1999;354:1169–73. https://doi.org/10.1016/S0140-6736(99)04093-3.
    27. Bellissima P, Bonfante S, La Spina G, Turturici MA, Bellissima G, Tricoli D. Complicanze della febbre bottonosa [Complications of mediterranean spotted fever]. Infez Med. 2001 Sep;9(3):158-62. Italian. PMID: 12087217.
    28. Ghezala HB, Feriani N. Rickettsiose invasive mortelle diagnostiquée tardivement en reanimation [Late diagnosis of fatal invasive rick-ettsial disease in the Intensive Care Unit]. Pan Afr Med J. 2016 Dec 6;25:211. French. https://doi.org/10.11604/pamj.2016.25.211.10452.
    29. Ben Mansour N, Barakett N, Haggui A, Filali T, Dahmen R, Fehri W. Une myocardite aiguë compliquant une fièvre boutonneuse médi-terranéenne. À propos d’un cas. Annales de cardiologie et d'angéiologie.Vol 63 - N° 1, P. 55-57 ; 2014. https://doi.org/10.1016/j.ancard.2011.05.003.
    30. Parola P, Paddock CD, Raoult D. Tick-borne rickettsioses around the world: Emerging diseases challenging old concepts. Clin Micro-biol Rev2005;18:719–56. https://doi.org/10.1128/CMR.18.4.719-756.2005.
    31. Estavoyer JM, Prost M, Brion JP, et al. Fièvre boutonneuse méditerranéenne avec atteinte oculaire et thrombose rétinienne. Bull Soc Ophtalmol Fr. 1985 ;85(9-10) :1045-8.
    32. Spernovasilis N, Markaki L, Papadakis M, Mazonakis N. Mediterranean Spotted Fever: Current Knowledge and Recent Advances. Trop. Med. Infect. Dis. 2021, 6(4), 172; https://doi.org/10.3390/tropicalmed6040172.
    33. Pitigoi D, Diana Olaru L, Rafila R. Mediterranean Spotted Fever in Southeastern Romania. BioMed Research InternationaJanuary 20132013(4):395806. https://doi.org/10.1155/2013/395806.
    34. Bouabdellah A, DELLAL L, Moumeni M. Fièvre Boutonneuse Méditerranéenne à Tlemcen http://dspace1.univ tlem-cen.dz/bitstream/112/10542/1.
    35. Botelho-Nevers E, Edouard S, Leroy Q, Raoult D. Deleterious, effect of ciprofloxacin on Rickettsia conorii-infected cells is linked to toxin-antitoxin module up-regulation. Journal of antimicrobial chemotherapy, 2012; 67(7) : 1677-1682 https://doi.org/10.1093/jac/dks089.
    36. Botelho-Nevers E, Rovery C, Richet H, Raoult D. Analysis of risk factors for malignant Mediterranean spotted fever indicates that fluo-roquinolone treatment has a deleterious effect. Journal of antimicrobial chemotherapy. 2011; 66(8): 1821-1830. https://doi.org/10.1093/jac/dkr218.
  • Downloads

  • How to Cite

    S., B., NH, A. ., M, F., HF, B. ., & F, S. (2025). Mediterranean spotted fever and its complications in Mostaganem, Algeria‎. International Journal of Medicine, 13(1), 1-7. https://doi.org/10.14419/xhk8y502

    Received date: February 3, 2025

    Accepted date: February 25, 2025

    Published date: February 25, 2025