Platelet rich fibrin in dentistry: A review of literature
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2015-08-26 https://doi.org/10.14419/ijm.v3i2.5079
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Healing, Growth Factors, Platelet Concentrates, Platelet Rich Fibrin, Regeneration. -
Abstract
The aim of any invasive procedure is the complete eradication and elimination of the infection and associated necrotic tissue followed by repair and regeneration of the affected tissue. In order to achieve this goal various biological products have been introduced, among which are present the platelet concentrates. Platelet concentrates with their higher concentration of platelets has been used in the field of medicine since the 1990s in the form of the first-generation concentrates-Platelet Rich Plasma, and the second generation concentrated -Platelet Rich Fibrin. Choukroun’s Platelet Rich Fibrin is one such material, which is used by itself and also as an adjunct with grafts. It has been successful as it delivers high doses of growth factors and has anti-inflammatory properties. They have been shown to be of great promise in the field of dentistry, ranging from implantology; Sinuses lift procedures, treating of endodontic and periodontal lesions to regeneration of necrotic pulp. This novel technique has the potential to revolutionize the treatment mode in dentistry and help with reducing patient morbidity. We will be further looking into the specification and implications of this material in this review.
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References
[1] Albrektsson T, Bach A, Edshage S &Jonsson A (1982): Fibrin adhesive system influence on Bone healing rate. A microradiographical evaluation.ActaOrthopScand53, 757-763.
[2] Albanese A, Licata ME, Polizzi B &Campisi G (2013): Platelet-rich plasma (PRP) in dental and oral surgery: from the wound healing to bone regeneration. Immun&Ageing, 10:23. http://dx.doi.org/10.1186/1742-4933-10-23.
[3] Bianco P& Robey PG (2001): Stem cells in tissue engineering.Nature 414, 118–121. http://dx.doi.org/10.1038/35102181.
[4] Burnouf T, Radosevich M &Goubran H (2008): Local hemostatic blood products in hemophilia care: fibrin sealant and platelet gel. In: Monograph, World Federation of Hemophilia. World Federation of Hemophilia, Montreal, 1-14.
[5] Choukroun J, Diss A, Simonpieri A, Girard MO, SchoefflerC, Dohan SL, Dohan AJ, Mouhyi J & Dohan DM (2006): Platelet-rich fibrin (PRF): a second-generation platelet concentrate. Part I: Technological concepts and evolution. Oral Surg Oral Med Oral Pathol Oral RadiolEndod 101, e37-e44. http://dx.doi.org/10.1016/j.tripleo.2005.07.012.
[6] Choukroun J, Diss A, Simonpieri A, Girard MO, SchoefflerC, Dohan SL, Dohan AJ, Mouhyi J & Dohan DM (2006): Platelet-rich fibrin (PRF): a second-generation platelet concentrate.Part II: Platelet-related biologic features. Oral Surg Oral Med Oral Pathol Oral RadiolEndod 101, e45-e50. http://dx.doi.org/10.1016/j.tripleo.2005.07.012.
[7] Choukroun J, Diss A, Simonpieri A, Girard MO, Schoeffler C, Dohan SL, Dohan AJ, Mouhyi J &Dohan DM (2006): Platelet-rich fibrin (PRF): a second-generation platelet concentrate.Part IV: Clinical effects on tissue healing. Oral Surg Oral Med OralPathol Oral RadiolEndod 101, e55-e60. http://dx.doi.org/10.1016/j.tripleo.2005.07.012.
[8] Choukroun J, Diss A, Simonpieri A, Girard MO, SchoefflerC, Dohan SL, Dohan AJ, Mouhyi J & Dohan DM (2006): Platelet-rich fibrin (PRF): a second-generation platelet concentrate. Part V: histologic evaluations of PRF effects on bone allograft maturation in sinus lift. Oral Surg Oral Med OralPathol Oral RadiolEndod101, 299-303. http://dx.doi.org/10.1016/j.tripleo.2005.07.012.
[9] Chowdhury S, Gokkulakrishnan S & K.Y Giri (2013): Use of Choukroun's Platelet Rich Fibrin in Oral Defects. Jdent Scioral rehabil Jan-March, 16 -20.
[10] Ehrenfest DM, de Peppo GM, Doglioli P &Sammartino G (2009): Slow release of growth factors and thrombospondin-1 in Choukroun’s platelet-rich fibrin (PRF): A gold standard to achieve for all surgical platelet concentrates technologies. Growth Factors 27, 63-69. http://dx.doi.org/10.1080/08977190802636713.
[11] Ehrenfest DM (2010): How to optimize the preparation of leukocyte-and platelet-rich fibrin (L-PRF, Choukroun's technique) clots and membranes: Introducing the PRF Box. Oral Surg Oral Med Oral Pathol Oral RadiolEndod 110(3), 275-278. http://dx.doi.org/10.1016/j.tripleo.2010.05.048.
[12] Ehrenfest DM, Del Corso M, Diss A, Mouhyi J & Charrier JB (2010): Three-dimensional architecture and cell composition of a Choukroun's platelet-rich fibrin clot and membrane. J PeriodontolApr 81 546-55. http://dx.doi.org/10.1902/jop.2009.090531.
[13] Ehrenfest DM, Bielecki T, Jimbo R, Barbe G, Del Corso M, Inchingolo F &Sammartino G (2012): Do the Fibrin Architecture and Leukocyte Content Influence the Growth Factor Release of Platelet Concentrates? An Evidence-based Answer Comparing a Pure Platelet-Rich Plasma (P-PRP) Gel and a Leukocyte- and Platelet-Rich Fibrin (L-PRF).Curr Pharm Biotechnol Jun 13(7), 1145-1152 http://dx.doi.org/10.2174/138920112800624382.
[14] Ehrenfest DM, Andia I, Zumstein MA, Zhang CQ, Pinto NR &Bielecki T (2014): Classification of platelet concentrates (Platelet-Rich Plasma-PRP, Platelet-Rich Fibrin-PRF) for topical and infiltrative use in orthopedic and sports medicine: current consensus, clinical implications and perspectives. Muscles, ligaments and tendons J.4, 3–9.
[15] Giannobile WV, Hernandez RA, Finkelman RD, Ryarr S, Kiritsy CP, D’Andrea M & Lynch SE(1996): Comparative effects of platelet-derived growth factor-BB and insulin-like growth factor-I, individually and in combination, on periodontal regeneration in Macacafascicularis. J Periodontal Res 31, 301–312. http://dx.doi.org/10.1111/j.1600-0765.1996.tb00497.x.
[16] He L, Lin Y, Hu X, Zhang Y &Wu H (2009): A comparative study of platelet-rich fibrin (PRF) and platelet-rich plasma (PRP) on the effect of proliferation and differentiation of rat osteoblasts in vitro. Oral Surg Oral Med Oral Pathol Oral RadiolEndod 108, 707-713. http://dx.doi.org/10.1016/j.tripleo.2009.06.044.
[17] Inchingolo F1, Tatullo M, Marrelli M, Inchingolo AM, Scacco S, Inchingolo AD, Dipalma G, Vermesan D, Abbinante A &Cagiano R (2010): Trial with Platelet-Rich Fibrin and Bio-Oss used as grafting materials in the treatment of the severe maxillar bone atrophy: clinical and radiological evaluations.Eur Rev Med PharmacolSci Dec 14 , 1075-84.
[18] Johns DA, Shivashankar VY, Shobha K &Johns M (2014): An innovative approach in the management of palatogingival groove using BiodentineTM and platelet-rich fibrin membrane. J Conserv Dent JCD 17, 75-79. doi:10.4103/0972-0707.124156. http://dx.doi.org/10.4103/0972-0707.124156.
[19] Kobayashi M1, Kawase T, Horimizu M, Okuda K, Wolff LF &Yoshie H (2012): A proposed protocol for the standardized preparation of PRF membranes for clinical use. Biologicals Sep 40, 323-9. doi: 10.1016/j.biologicals.2012.07.004. Epub 2012 Jul 28. http://dx.doi.org/10.1016/j.biologicals.2012.07.004.
[20] Khiste&Tari (2013): Platelet-Rich Fibrin as a Biofuel for Tissue Regeneration. ISRN Biomaterials Article ID 627367. doi:10.5402/2013/627367. http://dx.doi.org/10.5402/2013/627367.
[21] Lucarelli E , Beccheroni A, Donati D, Sangiorgi L, Cenacchi A, Del Vento AM, Meotti C, Bertoja AZ, Giardino R, Fornasari PM, Mercuri M &Picci P (2003):Platelet-derived growth factors enhance proliferation of human stromal stem cells. Biomaterials 24, 3095–3100. http://dx.doi.org/10.1016/S0142-9612(03)00114-5.
[22] L. Le Guéhennec, P Layrolle& G Daculsi (2004): A review of bioceramics and fibrin sealant. Eur Cell Mater 8, 1-10.
[23] Marx ER (1999): Platelet-rich plasma: A source of multiple autologous growth factors for bone grafts. In: Lynch SE, Genco RJ, Marx RE, editors. Tissue engineering, applications in maxillofacial surgery and periodontics, Quintessence Publishing Co, Inc Illinois, 71-82.
[24] Mazor Z, Horowitz RA, Del Corso M, Prasad HS, Rohrer MD & DohanEhrenfest DM (2009): Sinus floor augmentation with simultaneous implant placement using Choukroun’splateletrich fibrin as the sole grafting material: a radiologic and histologic study at 6 months. J Periodontol 80, 2056-64. http://dx.doi.org/10.1902/jop.2009.090252.
[25] Patel JS, Patel SG &Kadam C (2013):Choukroun's platelet rich fibrin in regenerative dentistry. Univ Res J Dent 3, 22-25. http://dx.doi.org/10.4103/2249-9725.119046.
[26] Qi Li, Pan S, Dangaria, Smit J , Gopinathan, Gokul, Kolokythas, Antonia, Chu S, Geng Y, Zhou Y &Luan X,Platelet-Rich Fibrin Promotes Periodontal Regeneration and Enhances Alveolar Bone Augmentation. BioMed Research International Article ID 638043 13 pages. doi:10.1155/2013/638043. http://dx.doi.org/10.1155/2013/638043.
[27] Raja & Naidu (2008): Platelet-rich fibrin: evolution of a second-generation platelet concentrate. Indian J Dent 19, 42–46. http://dx.doi.org/10.4103/0970-9290.38931.
[28] Simonpieri A, Del Corso M, Vervelle A, Jimbo R, Inchingolo F, Sammartino G &Dohan Ehrenfest DM (2012): Current knowledge and perspectives for the use of platelet-rich plasma (PRP) and platelet-rich fibrin (PRF) in oral and maxillofacial surgery part 2: Bone graft, implant and reconstructive surgery. Curr Pharm Biotechnol Jun 13, 1231-56. http://dx.doi.org/10.2174/138920112800624472.
[29] Shivashankar V Y, Johns DA, Vidyanath S &Ramesh Kumar M (2012): Platelet Rich Fibrin in the revitalization of tooth with necrotic pulp and open apex. J Conserv Dent. 15(4), 395–398. doi: 10.4103/0972-0707.101926 http://dx.doi.org/10.4103/0972-0707.101926.
[30] Shivashankar VY, Johns DA, Vidyanath S &Sam G (2013): Combination of platelet rich fibrin, hydroxyapatite and PRF membrane in the management of large inflammatory periapical lesion. J ConservDent 16, 261-4. http://dx.doi.org/10.4103/0972-0707.111329.
[31] Toffler M, ToscanoN, Holtzclaw D, Corso MD &Ehrenfest DD (2006): Introducing Choukroun’s Platelet Rich Fibrin (PRF) to the Reconstructive Surgery Milieu. J Imp AdvClinDent 1, 21-31.
[32] Yan MT (2006): The management of periapical lesions in endodonticallytreated teeth. AustEndodJ 32, 2–15. doi: 10.1111/j.1747-4477.2006.00002.x. http://dx.doi.org/10.1111/j.1747-4477.2006.00002.x.
[33] Zaky SH, CanceddaR (2009): Engineering craniofacial structures: facing the challenge. J Dent Res 88, 1077–1091. http://dx.doi.org/10.1177/0022034509349926.
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How to Cite
Ravi Kumar, V., & Gangadharan, G. (2015). Platelet rich fibrin in dentistry: A review of literature. International Journal of Medicine, 3(2), 72-76. https://doi.org/10.14419/ijm.v3i2.5079