Colorectal carcinoma in Sudanese patients

  • Authors

    • Mutaz Mohammed Sudan medical specialization board
    • Abd elmagid Musaad omdurman islamic university
    • Elsaggad Eltayeb Neelain university
    • Muataz A elaziz Neelain university
    2015-09-15
    https://doi.org/10.14419/ijm.v3i2.5159
  • Colorectal Cancer, Clinicopathological Pattern of Presentation, Adenocarcinoma, Postoperative Morbidity, Mortality.

  • Abstract

    Background: Cancer is an increasingly important public health problem in developing countries, including Sudan. The burden of colorectal cancer in Sudan is unknown, mainly because of lack of statistics or under reporting. Colorectal carcinoma is the most common malignancy of the GI tract, unfortunately there are few statistical data regarding colorectal cancer, its geographical, ethnic distribution, & pattern of behavior in Sudan.

    Objective: To assess pattern of presentation, management, & postoperative complication of colorectal carcinoma patients who presented to Ibn Sina hospital.

    Patients and method: This is a descriptive study between (2012-2014); a prospective & retrospective study of histological confirmed cases of colorectal cancer was conducted at Ibn Sina hospital.

    Result: Sixty three patients were included within the study. The mean age of the patients was 50.5 (±11.7). The median duration until presentation was 10 months. Left-side colonic carcinoma was 81% represented the majority of cases with Rectosigmoid cancer account for 74% of all cases. The most common presenting symptoms were alteration of bowel habits 90.5% and rectal bleeding 84%. Anemia was reported in 62.5% of right side colonic carcinoma while only in 23.5% of left colonic carcinoma. CEA was found positive in 85.3% (n=35). Postoperative morbidity in this study was 38%. All tumors were adenocarcinoma, and 65% of the sample were advanced “Duke's stage C & D."

    Conclusion: A younger age group with late presentation and advance disease, making the possibility of cure difficult if we take into consideration the scarcity of the resources.

  • References

    1. [1] A, A. et al., 2005. Postoperative mortality and morbidity in french patients undergoing colorectal surgery: Results of a prospective multicenter study. Archives of Surgery, 140(3), pp.278–283. Available at: http://dx.doi.org/10.1001/archsurg.140.3.278.

      [2] Abdalla, A.A.E., Alawad, A.A.M. & Ali, H.A.M., 2015. Pathologic response after neoadjuvant chemoradiotherapy in Sudanese patients with locally advanced rectal adenocarcinoma. International journal of medicine, 3(2), p.53. Available at: http://dx.doi.org/10.14419/ijm.v3i2.4836.

      [3] AbdallaA, M.M. & Randa, Z., 2007. Presentation of Colorectal Cancer in Khartoum Teaching Hospital. Sudan Journal of Medical Sciences, 2, pp.263–267.

      [4] Abdelrahim MI, S.S., 2010. The pattern and prevention of Colorectal cancer in Sudan. smj.

      [5] AO, P. et al., 2013. Prevalence and Pattern of Cancers among Adults Attending a Tertiary Health Institution in Lagos, Nigeria. Journal of Dental and Medical Sciences, 6(3), pp.68–73.http://dx.doi.org/10.9790/0853-0636873.

      [6] Ayyub, M.I. et al., 2002. Clinicopathological trends in colorectal cancer in a tertiary care hospital. Saudi medical journal, 23(2), pp.160–163.

      [7] Bailey, H. et al., 2013. Bailey & Love’s short practice of surgery 26th ed., CRC Press.

      [8] Bryant, C.L. et al., 2012. Anterior resection syndrome. The lancet oncology, 13(9), pp.e403–e408.http://dx.doi.org/10.1016/S1470-2045(12)70236-X.

      [9] Cappell, M.S., 2008. Pathophysiology, clinical presentation, and management of colon cancer. Gastroenterology Clinics of North America, 37(1), pp.1–24. Available at: http://dx.doi.org/10.1016/j.gtc.2007.12.002.

      [10] Chalya, P.L. et al., 2013. Clinicopathological patterns and challenges of management of colorectal cancer in a resource-limited setting: a Tanzanian experience. World J Surg Oncol, 11(1), pp.88–97. Available at: .http://dx.doi.org/10.1186/1477-7819-11-88.

      [11] Charles, B.F. et al., 2009. Schwartz’s principles of surgery, McGraw-Hill, Health Pub. Division.

      [12] Cucino, C., Buchner, A.M. & Sonnenberg, A., 2002. Continued rightward shift of colorectal cancer. Diseases of the colon & rectum, 45(8), pp.1035–1040. Available at: http://dx.doi.org/10.1007/s10350-004-6356-0.

      [13] Damhuis, R., Wereldsma, J. & Wiggers, T., 1996. The influence of age on resection rates and postoperative mortality in 6457 patients with colorectal cancer. International journal of colorectal disease, 11(1), pp.45–48. Available at: http://dx.doi.org/10.1007/BF00418856.

      [14] Davila, J.A. et al., 2005. Postoperative 30-day mortality following surgical resection for colorectal cancer in veterans: changes in the right direction. Digestive diseases and sciences, 50(9), pp.1722–1728. Available at: http://dx.doi.org/10.1007/s10620-005-2925-x.

      [15] Desnoo, L. & Faithfull, S., 2006. A qualitative study of anterior resection syndrome: the experiences of cancer survivors who have undergone resection surgery. European journal of cancer care, 15(3), pp.244–251. Available at: http://dx.doi.org/10.1111/j.1365-2354.2005.00647.x.

      [16] Duffy, M.J., 2001. Carcinoembryonic antigen as a marker for colorectal cancer: is it clinically useful? Clinical chemistry, 47(4), pp.624–630.

      [17] Elmasri, S. & Boulos, P., 1975. Carcinoma of the large bowel in the Sudan. British Journal of Surgery, 62(4), pp.284–286. Available at: http://dx.doi.org/10.1002/bjs.1800620408.

      [18] Freeny, P.C. et al., 1986. Colorectal carcinoma evaluation with CT: preoperative staging and detection of postoperative recurrence. Radiology, 158(2), pp.347–353. Available at: http://dx.doi.org/10.1148/radiology.158.2.3941861.

      [19] Gonzalez, E.C. et al., 2001. Predictors of proximalvs. distal colorectal cancers. Diseases of the colon & rectum, 44(2), pp.251–258. Available at: http://dx.doi.org/10.1007/BF02234301.

      [20] Hickey, B.B., 1959. Malignant Epithelial Tumours in the Sudanese: Hunterian Lecture delivered at the Royal College of Surgeons of England on 13th March 1958. Annals of the Royal College of Surgeons of England, 24(5), p.303.

      [21] Iacopetta, B., 2002. Are there two sides to colorectal cancer? International journal of cancer, 101(5), pp.403–408. Available at: http://dx.doi.org/10.1002/ijc.10635.

      [22] Johns, L.E. & Houlston, R.S., 2001. A systematic review and meta-analysis of familial colorectal cancer risk. The American journal of gastroenterology, 96(10), pp.2992–3003. Available at: http://dx.doi.org/10.1111/j.1572-0241.2001.04677.x.

      [23] Khan, M., Bari, H. & Raza, S., 2011. Early postoperative outcome after curative colorectal cancer surgery. Singapore medical journal, 52(3), pp.195–200.

      [24] Malik, M., El Din, Z. & El Masri, S., 1976. Cancer of the alimentary tract in the Sudan. A study of 546 cases. Cancer, 37(5), pp.2533–2542. Available at: http://dx.doi.org/10.1002/1097-0142(197605).

      [25] Miller, A., Gorska, M. & Bassett, M., 2000. Proximal shift of colorectal cancer in the Australian Capital Territory over 20 years. Australian and New Zealand journal of medicine, 30(2), pp.221–225. Available at: http://dx.doi.org/10.1111/j.1445-5994.2000.tb00811.x.

      [26] Nickelsen, T., Jørgensen, T. & Kronborg, O., 2005. Thirty-day mortality after surgery for colorectal cancer in Denmark. Colorectal disease, 7(5), pp.500–506. Available at: http://dx.doi.org/10.1111/j.1463-1318.2005.00793.x.

      [27] Papagiorgis, P.C. et al., 2014. Proximal shift of colorectal cancer. A persistent phenomenon with multiple causes, patterns and clinical implications. Journal of BU ON.: official journal of the Balkan Union of Oncology, 19(3), p.605.

      [28] Paun, B.C. et al., 2010. Postoperative complications following surgery for rectal cancer. Annals of surgery, 251(5), pp.807–818. Available at: http://dx.doi.org/10.1097/SLA.0b013e3181dae4ed.

      [29] Popoola, A. et al., 2012. Clinico-Pathological Presentation of Colorectal Cancer Seen in Lagos State University Teaching Hospital. Macedonian Journal of Medical Sciences, 5(4), pp.411–415. Available at: http://dx.doi.org/10.3889/MJMS.1857-5773.2012.0245.

      [30] Richman, S. & Adlard, J., 2002. Left and right sided large bowel cancer. Bmj, 324(7343), pp.931–932.http://dx.doi.org/10.1136/bmj.324.7343.931.

      [31] Saeed, I.E. et al., 2014. Cancer incidence in Khartoum, Sudan: first results from the Cancer Registry, 2009–2010. Cancer Medicine, 3(4), pp.1075–1084. Available at: http://dx.doi.org/10.1002/cam4.254.

      [32] Smith, D. et al., 2006. Symptomatic presentation of early colorectal cancer. Annals of the Royal College of Surgeons of England, 88(2), p.185. Available at: http://dx.doi.org/10.1308/003588406X94904.

      [33] Society, A.C., 2011. Colorectal Cancer Facts & Figures 2011-2013.

      [34] Souba, W.W. et al., 2007. ACS surgery: principles & practice 6th ed. D. M. O. Bruce M. Brenner, ed., WebMD Professional Pub.

      [35] Thoeni, R.F., 1997. Colorectal cancer. Radiologic staging. Radiologic Clinics of North America, 35(2), pp.457–485.

      [36] Willett, C.G., 2001. Cancer of the lower gastrointestinal tract C. G. Willett, ed., PMPH-USA.

  • Downloads

  • How to Cite

    Mohammed, M., Musaad, A. elmagid, Eltayeb, E., & A elaziz, M. (2015). Colorectal carcinoma in Sudanese patients. International Journal of Medicine, 3(2), 98-102. https://doi.org/10.14419/ijm.v3i2.5159

    Received date: 2015-08-07

    Accepted date: 2015-08-31

    Published date: 2015-09-15