Liposarcoma: experience in a tropical setting

  • Authors

    • Maurice Asuquo Department of Surgery, University of Calabar, Calabar
    • Martin Nnoli Department of Pathology, University of Calabar, Calabar
    • Victor Nwagbara Department of Surgery, University of Calabar, Calabar
    • John Ashindoitiang Department of Surgery, University of Calabar, Calabar
    • Theophilus Ugbem Department of Pathology, University of Calabar, Calabar
    • Samuel Akpan Department of Surgery, University of Calabar, Calabar
    2016-01-23
    https://doi.org/10.14419/ijm.v4i1.5673
  • Liposarcoma, Tropical setting.
  • Abstract

    Background: Virchow in 1860 described liposarcoma which arise from fat cells. It is a common soft tissue sarcoma found commonly in the limbs and retroperitoneum.

    Objectives: This study is an attempt to highlight the biographic indices, pattern, and challenges of management and outcomes of liposarcoma in a tropical setting and proffer solutions for improved outcome.

    Methods: Patients who presented to the University of Calabar Teaching Hospital from 2000-2014 with histologic diagnosis of liposarcoma were studied. This was compared with total soft tissue sarcoma and total malignancy seen during the same study period.

    Results: The 17 patients seen in the study period comprised 10 males and 7 females (M: F = 1.4:1) and their ages ranged from 37-70 years (mean 51 years). They accounted for 21.8% of soft tissue sarcoma and 0.9% of total malignancy. The commonest site involved was the lower limb 8(47%), while the abdomen ranked second 5(29%) with the retroperitoneum the commonest abdominal location. Pleomorphic liposarcoma was the commonest 8(47%) histologic type followed by myxoid 7(41%). The outcomes were generally poor with one hospital mortality. Sociocultural beliefs, ignorance and poverty were issues highlighted.

    Conclusions: Early presentation and diagnosis and treatment is advocated for improved outcome. Establishment of support groups in oncology will further provide health education services and compliment financing of treatment in view of the enormous cost of services and drugs.

  • References

    1. [1] Schwartz RA Liposarcoma 2015. Available at http://emedicine.medscape. Com/article/1102007-overview updated May 28th.

      [2] Turkoglu MH, Elpek GO, Dogru V, Calis H, Ucar A, Arici C 2014. An unusual case of primary colonic dedifferentiated liposarcoma. Int J of Surg Case Report 5: 8-11. http://dx.doi.org/10.1016/j.ijscr.2013.10.013.

      [3] Mentzel T, Fletcher CD 1995. Lipomatous tumours of soft tissues: an update. Virchows Arch 427(4):353-363. http://dx.doi.org/10.1007/BF00199383.

      [4] Weiss SW 1996. Lipomatous tumours. Monogr Pathol 38: 207-239.

      [5] Matthyssens LE, Creytens D, Ceelen WP 2015. Retroperitoneal liposarcoma: current insights in diagnosis and treatment. Frontiers in Surg 2/Article 4: 1-20

      [6] Hoffman A, Lazar AJ, Pollock RE, Lev D 2011. New frontiers in treatment of liposarcoma, a therapeutically resistant malignant cohort. Drug Resist. Updat.14 (1): 52-66. http://dx.doi.org/10.1016/j.drup.2010.11.001.

      [7] Dei Tos AP 2000. Liposarcoma new entities and evolving concepts. Ann Diagn Pathol 4(4): 252-266. http://dx.doi.org/10.1053/adpa.2000.8133.

      [8] Costea R, Vasiliu E, Zamescu NO, HasounaM, Neagu S, Davila C 2011. Large thigh liposarcoma- Diagnostic and therapeutic features. Journal of Medicine and Life 4(2): 184-188.

      [9] Nemanqani D, Mourad WA, Akhtar M, Moreau P, Rostom A, Ezzat A, Amin T 1999. Liposarcoma: A clinicopathological study of 73 cases diagnosed at King Faisal Specialist Hospital and Research Centre. Ann Saudi Med 19(4): 299-303.

      [10] Orvieto E, Furlanetto A, Laurino L, Dei Tos AP 2001. Myxoid and round cell liposarcoma: a spectrum of myxoid adipocytic neoplasia. Semin Diagn Pathol 18(4): 267-273.

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  • How to Cite

    Asuquo, M., Nnoli, M., Nwagbara, V., Ashindoitiang, J., Ugbem, T., & Akpan, S. (2016). Liposarcoma: experience in a tropical setting. International Journal of Medicine, 4(1), 6-9. https://doi.org/10.14419/ijm.v4i1.5673

    Received date: 2015-12-21

    Accepted date: 2016-01-18

    Published date: 2016-01-23