Neurofibrosarcoma: case series in south-south Nigeria

  • Abstract
  • Keywords
  • References
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  • Abstract

    Neurofibrosarcoma is a malignancy that occurs more frequently in patients with neurofibromatosis- 1 (NF- 1) and rarely may arise independently. This is a presentation of 3 consecutive patients with histologic diagnosis of neurofibrosarcoma who presented to the University of Calabar Teaching Hospital, Calabar from 2011-2013. Two patients presented were associated with NF-1 and were a decade younger than the one without NF-1. Late presentation and poor follow up were notable underlying factors. Long term follow up of patients with NF -1 for early diagnosis and adequate treatment will improve outcome.

  • Keywords

    Neurofibrosarcoma; Neurofibromatosis -1; Neurofibroma.

  • References

      [1] Asuquo ME (2005) Neurofibromatosis – Complicating Neurofibromatosis – 1: Case Report and Review of Relevant Literature. Nig Postgrad Med J 12(3): 233-236

      [2] Riccardi VM, Powell PP (1989) Neurofibrosarcoma as a complication of von Recklinghausen neurofibromatosis. Neurofibromatosis 2(3): 152-165

      [3] Sar C, Eraip L (2002) Metastatic spinal neurofibrosarcoma. Arch Orthop Trauma Surg 122(2): 106-108

      [4] Liu X, Tang K, Siu L, Xu G (2013) Neurofibroma of the gallbladder: a case report. World Journal of Surgical Oncology 11: 189 (pp 1-4)

      [5] Storm FK, Eilber FR, Mirra J, Morton DL (1980) Neurofibrosarcoma. Cancer 45: 126-129<126::AID-CNCR2820450122>3.0.CO;2-U.

      [6] Nwagbara V, Asuquo M, Akpan S, Eduwem D, Omotoso A, Ugbem T (2013) Giant solitary intermuscular cystic plexiform neurofibroma of the thigh: A case report and literature review. Int J Case Report med

      [7] Neville BW, Hann J, Narang R, Garen P (1991) Oral neurofibrosarcoma associated with neurofibromatosis type-1. Oral Surg Oral Med Oral Pathol 72(4): 456-461

      [8] Etiuma AU, Bassey OO, Asuquo ME, Ebughe G (2007) Multiple Neurofibrosarcoma in a Patient with Neurofibromatosis -1. A case report. Nig J Surg 13(1-2): 29-31

      [9] Dabski C, Reiman HM, Muller SA (1990) Neurofibrosarcoma of the skin and subcutaneous tissues. Mayo Clin Proc 65(2): 164-172

      [10] Odebode TO, Afolanyan EAO, Adigun IA, Daramola OOM (2005) Clinicopathological study of neurofibromatosis type-1: an experience in Nigeria. Int J Dermatol 44: 116-120

      [11] Banerjee R, Bandopadhyay D, Abilash VG (2013) Epidemiology, pathology, types and diagnosis of soft tissue sarcoma: A Research Review. Asian J Pharm Clin Res 6(suppl 3): 18-25.

      [12] Asuquo ME, Nnoli M, Nwagbara VIC, Ashindoitiang J, Ugbem T, Akpan S (2016) Liposarcoma: experience in a tropical setting. Int J Med 4(1): 6-9.

      [13] Nyandaiti YW, Tahir C, Nggada HA, Ndahi AA (2009) Clinicopathologic presentation and management of neurofibromatosis among north-eastern Nigerians: A six year review. Nig Med J 50(4): 80-83.

      [14] Neville H, Corpron C, Blakely ML, Andrassy R (2003) Paediatric Neurofibrosarcoma. J Pediatr Surg 38(3): 343-346.

      [15] Mankin HJ, Homicek FJ (2005) Diagnosis, classification and management of soft tissue sarcomas. Cancer Control 12: 5-21.




Article ID: 6297
DOI: 10.14419/ijm.v5i1.6297

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