Non-physiological antioxidants: How safe?

  • Authors

    • Muhammad Islam LecturerDepartment of PharmacySouthern University BangladeshMehedibag-4000, Chittagong
    2017-01-30
    https://doi.org/10.14419/ijm.v5i1.7064
  • Non-Physiologic Antioxidants, Oxidative Stress, Precautions.

  • Antioxidants of various origins, by these days are one of the known health promotion tools in the world. These are also vastly used as over-the-counter medications. Having a protective capacity, antioxidants have been procured much attention in various fields; these include- dietary consumption, medicinal and cosmetic preparations, food and drinks preparation and preservation, and so on. Antioxidants are more concerned with the medical and pharmaceutical fields, where therapeutic applications are the prime apprehension. Our body has a number of antioxidants called physiological antioxidant systems. Generally, antioxidants are the reducing agents. A failure of balance between the production of oxidative substances and internal or physiological antioxidant molecules asks us to intake external or non-physiological antioxidants. How safe the non-physiological antioxidants? This text sketches theoretically a short scenario on safety and precautions of biologically installation of non-physiological antioxidants. This article is an update of previously published article by EC Orthopaedics 5.2 (2017): 29-31, where the author reserves all rights.

  • References

    1. [1] Kamata H, Hirata H. Redox regulation of cellular signaling. Cell Signal 1999; 11:1-14. https://doi.org/10.1016/S0898-6568(98)00037-0.

      [2] Islam MT. Concentration-Dependent-Activities of Diterpenes: Achieving Anti-/Pro-Oxidant Links. Asian J Ethnopharmacol Med Foods 2016; 2(4):12-15.

      [3] Poljsak B, Milisav I. The neglected significance of antioxidative stress. Oxidative Med Cellul Longev 2012; 12 pages. PMID: 480895.

      [4] Gupta SC, Hevia D, Patchva S, Park B, Koh W, Aggarwal BB. Upsides and downsides of reactive oxygen species for cancer: the roles of reactive oxygen species in tumorigenesis, prevention, and therapy. Antiox Redox Signaling 2012; 16:1295-1322. https://doi.org/10.1089/ars.2011.4414.

      [5] Yang W, Li J, Hekimi SA. Measurable increase in oxidative damage due to reduction in superoxide detoxification fails to shorten the life span of long-lived mitochondrial mutants of Caenorhabditis elegans. Genet 2007; 177:2063-2074. https://doi.org/10.1534/genetics.107.080788.

      [6] Chatoo W, Abdouh M, David J, Champagne M-P, Ferreira J, Rodier F, et al. The polycomb group gene Bmi1 regulates antioxidant defenses in neurons by repressing p53 pro-oxidant activity. J Neurosci 2009; 29:529-542. https://doi.org/10.1523/JNEUROSCI.5303-08.2009.

      [7] Liu J, Cao L, Chen J, Song S, Lee IH, Quijano C, et al. Bmi1 regulates mitochondrial function and the DNA damage response pathway. Nature 2009; 459:387-392. https://doi.org/10.1038/nature08040.

      [8] Li TS, Marban E. Physiological levels of reactive oxygen species are required to maintain genomic stability in stem cells. Stem Cells 2010; 28:1178-1185. https://doi.org/10.1002/stem.438.

      [9] Islam MT, Streck L, Paz MFCJ, Sousa JMC, Alencar MVOB, Mata AMOF, Carvalho RM, Jose Santos JVO, Silva-Junior AA, Ferreira PMP, Melo-Cavalcante AAC. Preparation of phytol-loaded nanoemulsion and screening for antioxidant capacity. Int Arch Med 2016; 9(70):1-15. https://doi.org/10.3823/1941.

      [10] Gutteridge JMC. Free radicals in disease processes: a compilation of cause and consequence. Free Radic Res Comm 1993; 19:141-158. https://doi.org/10.3109/10715769309111598.

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  • How to Cite

    Islam, M. (2017). Non-physiological antioxidants: How safe?. International Journal of Medicine, 5(1), 41-44. https://doi.org/10.14419/ijm.v5i1.7064