Anti-nociceptive and antipyretic activities of Solanum violaceum ortega

  • Abstract
  • Keywords
  • References
  • PDF
  • Abstract

    Solanum violaceum Ortega has been used by the traditional medicine practitioners in pain and fever. This study aimed at investigating anti-nociceptive and antipyretic activities of methanol extract of leaf (MELSV), fruit (MEFSV) and root (MERSV) of S. violaceum in Swiss albino mice. Anti-nociceptive activity was evaluated using hot plate method while antipyretic by brewer’s yeast induced hyperpyrexia. In both tests, test animals were divided into eight groups of six in each. The groups were treated as negative control (distilled water), standard and tests (250 and 500 mg/kg of MELSV/ MERSV/ MERSV). Diclofenac sodium (150 mg/kg) and paracetamol (150 mg/kg) were taken as standards for anti-nociceptive and antipyretic tests, respectively. All the treatments were administrated via oral gavages (p.o.). Results suggest that, the plant extracts dose-dependently increased retention time compared to the control groups. MELSV at 500 mg/kg significantly increased retention time on the hot-pate of the test animals than the MEFSV and MERSV treated groups. In the antipyretic test, both 250 and 500 mg/kg of MELSV and 500 mg/kg of MEFSV significantly (p <0.05) decreased temperature to the experimental animals 30, 60, 120 minutes. In conclusion, the crude extracts of S. violaceum exhibited anti-nociceptive and antipyretic activities. S. violaceum may be one of the good sources of anti-nociceptive and antipyretic compounds.

  • Keywords

    Anti-inflammation; Pain; Fever; Mus musculus.

  • References

      [1] Kaur S, Jaggi RK. Analgesic activity of chronic administration of different extracts of Terminalia bellerica Roxb. and Terminalia chebula Retz. Fruits. Indian J Exp Biol 2010; 48:925-930.

      [2] Islam MT, Mata AMOF, Aguiar RPS, Paz MFCJ, Alencar MVOB, Melo-Cavalcante AAC. Therapeutic Potential of Essential Oils Focusing on Diterpens. Phytother Res 2016a; 30:1420-1444.

      [3] Rates SMK. Plants as source of drugs. Toxicon 2001; 39:603-613.

      [4] Olmstead RG, Bohs L. A summary of molecular systematic research in Solanaceae: 1982-2006; VI International Solanaceae Conference: Genomics Meets Biodiversity: Madison, Wisconsin, USA, 2006; p. 255-268.

      [5] Jain SK, Borthakur SK. Solanaceae in Indian tradition, folklore, and medicine; Solanaceae: Biology and Systematics: Colombia University Press, New York, USA, 1986; p. 75-138.

      [6] Malek I, Islam T, Hasan E, Akter S, Rana M, Das PR, et al. Medicinal plants used by the Mandais- a little known tribe of Bangladesh. Afr J Tradit Complement Altern Med 2012; 9: 536-541.

      [7] Seraj S, Jahan FI, Chowdhury AR, Monjur-Ekhuda M, Khan MSH, Aporna SA, et al. Tribal formulations for treatment of pain: A study of the Bede community traditional medicinal practitioners of Porabari village in Dhaka district, Bangladesh. Afr J Tradit Complement Altern Med 2013; 10:26-34.

      [8] Raghavendra MP, Prasad AD, Shyma TB. Investigations on anti-diabetic medicinal plants used by tribes of Wayanad district, Kerala. Int J Pharm Sci Res 2015; 6:3617-3625.

      [9] Singh N, Singh B, Vashistha BD. Genus Solanum L. in North and North-eastern Haryana (India): diversity, ecological status and ethnobotanical significance. Phytodivers 2014; 1:31-42.

      [10] BEOD (Bangladesh ethnobotany online database). Available online: (Accessed on 10 October 2015).

      [11] MPB (Medicinal plants of Bangladesh). Available online: (Accessed on 10 October 2015).

      [12] Chang FR, Yen CT, El-Shazly M, Yu CY, Yen MH, Cheng YB, et al. Spirostanoids with 1, 4-dien-3-one or 3β, 7α-diol-5, 6-ene moieties from Solanum violaceum. Bioorg Med Chem Lett 2013; 23:2738-2742.

      [13] Bu M, Yang BB, Hu L. Natural Bioactive Sterol 5α, 8α-endoperoxides as Drug Lead Compounds. Med Chem 2014; 4:709-716.

      [14] Manjunatha BK. Wound healing activity of Solanum violaceum Ortega. Indian Drugs 2006; 3:835.

      [15] Raju GS, Moghal MMR, Dewan SMR, Amin MN, Billah MM. Characterization of phytoconstituents and evaluation of total phenolic content, anthelmintic, and antimicrobial activities of Solanum violaceum Ortega. Avicenna J Phytomed 2013; 3:313-320.

      [16] Tzekuei C, Tsuiching C. Antioxidant properties of methanolic and hot water extracts from some medicinal plants. Tai J Agri Chem Food Sci 2009; 47:260-267.

      [17] Yen CT, Lee CL, Chang FR, Hwang TL, Yen HF, Chen CJ, et al. Indiosides G–K: Steroidal glycosides with cytotoxic and anti-inflammatory activities from Solanum violaceum. J Nat Prod 2012; 75:636-643.

      [18] Sultana N, Islam MT, Alencar MVOB, Silva SWC, Chowdhury MMU, Melo-Cavalcante AAC, et al. Phyto-pharmacological screenings of two Rubiaceae family plants. Afric J Pharm Pharmacol 2015; 9:775-782.

      [19] Nur T, Islam MT, Alam S, Chowdhury MMU, Melo-Cavalcante AAC, Freitas RM. Pharmacological investigations of organic crude fractions of Dysophylla auricularia. Orient Pharm Exp Med 2015; 15:207-215.

      [20] Cao YQ, Mantyh PW, Carlson EJ, Gillespie AM, Epstein CJ, Basbaum AI. Primary afferent tachykinins are required to experience moderate to intense pain. Nature 1998; 392:390-394.

      [21] Conaghan PG. A turbulent decade for NSAIDs: update on current concepts of classification, epidemiology, comparative efficacy, and toxicity. Rheumatol Int 2012; 32:1491-1502.

      [22] Mi E, Ezeigbo II, Madubuike KG. Analgesic activity of the methanolic seed extract of Buchholzia coriacea. Res J Pharmaceut Biol Chem Sci 2011; 2:187.

      [23] Omeh YS, Ezeja MI. Analgesic activity of the methanolic leaf extract of Jatropha curcas (Linn). Afr J Biomed Res 2013; 13:149-152.

      [24] Sharma N, Aggarwal SG, Kala RP, Kumar A. Analgesic activity of Swertia chirayita. World J Pharm Pharmaceut Sci 2013; 2:3667-3675.

      [25] Islam MT, Silva CB, Alencar MVOB, Paz MFCJ, Almeida FRC, Melo-Cavalcante AAC. Diterpenes: Advances in Neurobiological Drug Research. Phytother Res 2016b; 30:915-928.

      [26] Chattopadhyay D, Arunachalam G, Ghosh L, Rajendran K, Manda AB, Bhattacharya SK. Antipyretic activity of Alstonia macrophylla Wall ex A. DC: an ethnomedicine of Andaman Islands. J Pharm Pharmaceut Sci 2005; 8:558-564.

      [27] Qadrie ZL, Hawisa NT, Khan MWA, Samuel M, Anandan R. Antinociceptive and anti-pyretic activity of Benincasa hispida (Thunb.) Cogn. in Wistar albino rats. Pak J Pharm Sci 2009; 22:287-290.

      [28] Alzubier AA, Okechukwu PN. Investigation of anti-inflammatory, antipyretic and analgesic effect of Yemeni Sid honey. World Acad Sci Engr Technol 2011; 80:47-52.

      [29] Ridtitid W, Ruangsang P, Reanmongkol W, Wongnawa M. Studies of the anti-inflammatory and antipyretic activities of the methanolic extract of Piper sarmentosum Roxb. leaves in rats. Studies 2007; 29:1519-1526.

      [30] Mutalik S, Paridhavi K, Rao CM, Udupa N. Antipyretic and analgesic effect of leaves of Solanum melongena Linn. in rodents. Indian J Pharmacol 2003; 35:312-315.




Article ID: 7282
DOI: 10.14419/ijm.v5i1.7282

Copyright © 2012-2015 Science Publishing Corporation Inc. All rights reserved.