Genotoxic and mutagenic effects of triterpenes: A mini-review

  • Authors

    • Muhammad Islam LecturerDepartment of PharmacySouthern University BangladeshMehedibag-4000, Chittagong
    2017-06-27
    https://doi.org/10.14419/ijm.v5i2.7800
  • Natural Products, Safety Potentials, Triterpenes.

  • Abstract

    This review sketches genotoxic and mutagenic potentials of triterpenes, which find outs some important genotoxic, mutagenic as well as non-genotoxic and non-mutagenic triterpenes. Triterpeners are the important natural products.

  • References

    1. [1] Aguilar-Santamaría L, Ramírez G, Herrera-Arellano A, Zamilpa A, Jiménez JE, Alonso-Cortés D, Cortés-Gutiérrez EI, Ledesma N, Tortoriello J. 2007. Toxicological and cytotoxic evaluation of standardized extracts of Galphimia glauca. J. Ethnopharmacol. 109(1):35-40. https://doi.org/10.1016/j.jep.2006.06.013.

      [2] Araújo Sde S, Fernandes TC, Cardona YT, Almeida PM, Marin-Morales MA, Dos Santos AV, Randau KP, Benko-Iseppon AM, Brasileiro-Vidal AC. 2015. Cytotoxic and genotoxic effects of ethanolic extract of Euphorbia hyssopifolia L. on HepG2 cells. J. Ethnopharmacol. 170:16-19. https://doi.org/10.1016/j.jep.2015.04.044.

      [3] de Freitas PL, Dias AC, Moreira VR, Monteiro SG, Pereira SR. 2015. Antimutagenic action of the triterpene betulinic acid isolated from Scoparia dulcis (Scrophulariaceae). Genet. Mol. Res. 14(3):9745-52. doi: 0.4238/2015.

      [4] El Hosry L, Di Giorgio C, Birer C, Habib J, Tueni M, Bun SS, Herbette G, De Meo M, Ollivier E, Elias R. 2014. In vitro cytotoxic and anticlastogenic activities of saxifragifolin B and cyclamin isolated from Cyclamen persicum and Cyclamen libanoticum. Pharm. Biol. 52(9):1134-1140. https://doi.org/10.3109/13880209.2013.879600.

      [5] Islam MT, Ali ES. 2016. Therapeutic interventions of diterpenes: Molecular mechanisms and promises. World J. Pharm. Pharmaceut. Sci. 5(10):70-97.

      [6] Islam MT. 2016. Safety promises of diterpenes concerning on toxicogenetic effects. BAOJ Chem. 2(2):1-5.

      [7] Khalil WK, Ahmed KA, Park MH, Kim YT, Park HH, Abdel-Wahhab MA. 2008. The inhibitory effects of garlic and Panax ginseng extract standardized with ginsenoside Rg3 on the genotoxicity, biochemical, and histological changes induced by ethylenediaminetetraacetic acid in male rats. Arch. Toxicol. 82(3):183-195. https://doi.org/10.1007/s00204-007-0237-y.

      [8] Kwankua W, Sengsai S, Kuleung C, Euawong N. 2010. Sunlight decreased genotoxicity of azadirachtin on root tip cells of Allium cepa and Eucrosia bicolor. Ecotoxicol. Environ. Saf. 73(5):949-954. https://doi.org/10.1016/j.ecoenv.2010.04.001.

      [9] Mosesso P, Bohm L, Pepe G, Fiore M, Carpinelli A, Gäde G, Nagini S, Ottavianelli A, Degrassi F. 2012. Cytogenetic analyses of Azadirachtin reveal absence of genotoxicity but marked antiproliferative effects in human lymphocytes and CHO cells in vitro. Toxicol. Lett. 213(3):361-366. https://doi.org/10.1016/j.toxlet.2012.07.021.

      [10] Ngassapa O, Beecher CW, Pezzuto JM, Farnsworth NR, Henderson TO, Boye GL. 1993. Isolation of echinocystic acid-3-O-sulfate, a new triterpene, from Tetrapleura tetraptera, and evaluation of the mutagenic potential of molluscicidal extracts and isolates. J. Nat. Prod. 56(11):1872-1877. https://doi.org/10.1021/np50101a002.

      [11] Pabón A, Blair S, Carmona J, Zuleta M, Saez J. 2003. Evaluation of the mutagenicity of antimalarial products isolated from Solanum nudum (Solanaceae). Pharmazie. 58(4):263-267.

      [12] Polikarpova SI, Volkova ON, Sedov AM, Stonik VA, Likhoded VG. 1990. Cytogenetic study of the mutagenicity of cucumarioside. Genetika. 26(9):1682-1685.

      [13] Przybojewska B, Barański B, Spiechowicz E, Dziubałtowska E, Szymczak W. 1994. Potential carcinogenicity assessment of alpha-aescin and phenbendasol. Acta Pol. Pharm. 51(1):89-93.

      [14] Rosenkranz HS, Klopman G. 1995. An examination of the potential "genotoxic" carcinogenicity of a biopesticide derived from the neem tree. Environ. Mol. Mutagen. 26(3):255-260. https://doi.org/10.1002/em.2850260311.

      [15] Villaseñor IM, Canlas AP, Faustino KM, Plana KG. 2004. Evaluation of the bioactivity of triterpene mixture isolated from Carmona retusa (Vahl.) Masam leaves. J. Ethnopharmacol. 92(1):53-56. https://doi.org/10.1016/j.jep.2004.01.017.

      [16] Wang Z, Zheng Q, Liu K, Li G, Zheng R. 2006. Ginsenoside Rh (2) enhances antitumour activity and decreases genotoxic effect of cyclophosphamide. Basic Clin. Pharmacol. Toxicol. 98(4):411-415. https://doi.org/10.1111/j.1742-7843.2006.pto_348.x.

      [17] Zani F, Cuzzoni MT, Daglia M, Benvenuti S, Vampa G, Mazza P. 1993. Inhibition of mutagenicity in Salmonella typhimurium by Glycyrrhiza glabra extract, glycyrrhizinic acid, 18 alpha- and 18 beta-glycyrrhetinic acids. Planta Med. 59(6):502-507. https://doi.org/10.1055/s-2006-959748.

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  • How to Cite

    Islam, M. (2017). Genotoxic and mutagenic effects of triterpenes: A mini-review. International Journal of Medicine, 5(2), 167-168. https://doi.org/10.14419/ijm.v5i2.7800

    Received date: 2017-05-18

    Accepted date: 2017-06-17

    Published date: 2017-06-27