Vitamin A in prevention and treatment of cancer

  • Authors

    • Ricardo Carvalho Post-graduate Program in Pharmaceutical Science, Federal University of Piauí, Teresina, Piauí, Brazil
    • Muhammad Islam Postgraduate Program in Pharmaceutical Sciences, Federal University of Piauí, Teresina (Piauí)-64.049-550, Brazil.
    • Ana Mata Post-graduate Program in Pharmaceutical Science, Federal University of Piauí, Teresina, Piauí, Brazil
    • Reyca e Silva Laboratory of Treatment of Materials, Federal Institute of Piauí, Teresina, Piauí, Brazil
    • Márcia Paz Post-graduate Program in Pharmaceutical Science, Federal University of Piauí, Teresina, Piauí, Brazil
    • Marcus Alencar Postgraduate Program in Pharmaceutical Sciences, Federal University of Piauí, Teresina (Piauí)-64.049-550, Brazil.
    • Hercília Rolim Postgraduate Program in Pharmaceutical Sciences, Federal University of Piauí, Teresina (Piauí)-64.049-550, Brazil.
    • Maria Medeiros Postgraduate Program in Pharmaceutical Sciences, Federal University of Piauí, Teresina (Piauí)-64.049-550, Brazil.
    • João e Sousa Department of Biological Sciences, Federal University of Piauí, Picos (Piauí), 64.607-670, Brazil.
    • Ana Amélia Melo-Cavalcante Postgraduate Program in Pharmaceutical Sciences, Federal University of Piauí, Teresina (Piauí)-64.049-550, Brazil.
    2017-07-16
    https://doi.org/10.14419/ijm.v5i2.7947
  • , Vitamin A, Oxidative Stress, Cancer.
  • Dietary components not only act as chemo preventive agents but also risk factors in the onset of cancer, which stimulating nutritional bal-ance in cancer or non-cancer populations. The supplementation of antioxidant compounds, such as vitamin A (Vit A) and few of its deriva-tives has been reported to alleviate the oxidative stress in cancer patients. This review focuses on sketching a current scenario on the Vit A role in cancer prevention and therapy. Therefore, we searched for published article on PubMed and Science Direct between 2014 and 2015. The search yielded 75 articles related to Vit A-mediated anti-oxidative or pro-oxidative effects in cancer patients. A low dose-mediated anti-cancer effect was observed with Vit A in some cancers. The clinical studies showed discrepancies between the low and high doses of Vit A in cancer. In conclusion, precautions are needed in taking Vit A and its derivatives, especially in cancer.

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    Carvalho, R., Islam, M., Mata, A., e Silva, R., Paz, M., Alencar, M., Rolim, H., Medeiros, M., e Sousa, J., & Melo-Cavalcante, A. A. (2017). Vitamin A in prevention and treatment of cancer. International Journal of Medicine, 5(2), 199-205. https://doi.org/10.14419/ijm.v5i2.7947