Severe Ulcerative Colitis Flare Unmasking Factor VII Deficiency

 
 
 
  • Abstract
  • Keywords
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  • Abstract


    We present a 22-year-old male with severe bleeding from Ulcerative Colitis. Workup revealed anemia and elevated prothrombin time, with subsequent mixing study and clotting factor levels revealing factor VII deficiency. Bleeding disorders such as Factor VII deficiency may exacerbate the degree of hemorrhage in inflammatory bowel disease flares, making prompt recognition of underlying coagulopathies crucial.


  • Keywords


    Gastrointestinal Bleeding; Ulcerative Colitis; Factor VII Deficiency.

  • References


      [1] Ordas I, Eckmann L, Talamini M, Baumgart DC, Sandborn WJ. Ulcerative Colitis. Lancet 2012; 380: 1606-1619. https://doi.org/ 10.1016/S0140-6736(12)60150-0.

      [2] Mariani G, Bernardi F. Factor VII Deficiency. Seminars in Thrombosis and Hemostasis 2009; 35: 400-406. https://doi.org/10.1055/s-0029-1225762.

      [3] Lapecorella M, Mariani G. Factor VII deficiency: defining the clinical picture and optimizing therapeutic options. Haemophilia 2008; 14(6): 1170-1175. https://doi.org/10.1111/j.13652516.2008.01844.x.

      [4] Sevenet P, Kaczor DA, Depasse F. Factor VII Deficiency: From Basics to Clinical Laboratory Diagnosis and Patient Management. Clin Appl Thromb Hemost 2016. https://doi.org/10.1177/107 6029616670257.

      [5] Freeney M, Talbot R, Worsley A, Snook J. Crohn’s disease and inherited coagulopathy: two case reports. Ital J Gastroenterol Hepatol 1998; 30(4): 442.


 

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Article ID: 8840
 
DOI: 10.14419/ijm.v6i1.8840




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