Severe Ulcerative Colitis Flare Unmasking Factor VII Deficiency

  • Abstract
  • Keywords
  • References
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  • Abstract

    We present a 22-year-old male with severe bleeding from Ulcerative Colitis. Workup revealed anemia and elevated prothrombin time, with subsequent mixing study and clotting factor levels revealing factor VII deficiency. Bleeding disorders such as Factor VII deficiency may exacerbate the degree of hemorrhage in inflammatory bowel disease flares, making prompt recognition of underlying coagulopathies crucial.

  • Keywords

    Gastrointestinal Bleeding; Ulcerative Colitis; Factor VII Deficiency.

  • References

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      [2] Mariani G, Bernardi F. Factor VII Deficiency. Seminars in Thrombosis and Hemostasis 2009; 35: 400-406.

      [3] Lapecorella M, Mariani G. Factor VII deficiency: defining the clinical picture and optimizing therapeutic options. Haemophilia 2008; 14(6): 1170-1175.

      [4] Sevenet P, Kaczor DA, Depasse F. Factor VII Deficiency: From Basics to Clinical Laboratory Diagnosis and Patient Management. Clin Appl Thromb Hemost 2016. 6029616670257.

      [5] Freeney M, Talbot R, Worsley A, Snook J. Crohn’s disease and inherited coagulopathy: two case reports. Ital J Gastroenterol Hepatol 1998; 30(4): 442.




Article ID: 8840
DOI: 10.14419/ijm.v6i1.8840

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